Brand name: Cipro.
Main ingredient: Ciprofloxacin hydrochloride.
Group: antibacterial drugs, derivatives of fluoroquinolones.
Product: white or orange pills, round to oval in shape depending on the dosage and manufacturer.
Pharmacology of Cipro
This drug acts by blocking the production of DNA gyrase in bacterial cells. This active enzyme is required for the synthesis of DNA for new cells. As a result there is an inhibition of protein synthesis in the bacterial cells and new DNA from the parent DNA is not formed.
Cipro is active against bacteria that are not reproducing and also against the ones that are reproducing.
The drug is absorbed well from the gastrointestinal tract, especially if taken on an empty stomach. Peak plasma concentration is achieved about one to two hours after consumption.
The highest concentration of ciprofloxacin is found in:
- prostate gland;
- fallopian tubes and ovaries;
Significant concentrations are also found in bronchial secretions, bony and muscular tissue, skin, eye fluid, lymphatic fluid, saliva, pleura, and peritoneum.
Half-life of the substance is approximately four hours. The drug is mainly excreted by the kidneys through urine and faeces.
Methods of administration and dosage of Cipro
This drug should be taken on an empty stomach; pills must be swallowed along with an appropriate amount of liquid.
Dosage is determined by the attending physician depending on the type of disease and the severity of its course, the age and weight of the patient as well as status of renal function:
- for infections of the genitourinary system without any complications: 0.25 g twice a day; duration of treatment is three days;
- complicated upper and lower urinary tract infections: 0.5 g twice a day; duration of treatment is up to two weeks;
- severe pneumonia and osteomyelitis: 0.75 g twice a day; duration of treatment is from four to six weeks;
- carrier state of salmonella infection: 0.75 g twice a day; duration of treatment is four weeks;
- bacterial gastroenteritis: 0.5 g twice a day; duration of treatment is five to seven days, but may be increased up to two weeks.
Treatment of patients with impaired renal function and elderly patients is carried out after making necessary adjustments to the dose based on the level of serum creatinine and severity of the disease.
You can buy Cipro without a prescription, but that does not relieve the patients from the need for professional consultation of a specialist.